COMPUTATIONAL IDENTIFICATION OF PUTATIVE DRUG TARGETS IN MALASSEZIA GLOBOSA BY SUBTRACTIVE GENOMICS AND PROTEIN CLUSTER NETWORK APPROACH
نویسندگان
چکیده
منابع مشابه
Identification of putative drug targets of Listeria monocytogenes F2365 by subtractive genomics approach
Article info: Received: 28 November 2012 Accepted: 1 March 2013 ABSTRACT The prolonged and uncontrolled use of antibiotics in treatment against many pathogens causes the multiple drug resistance. The drug resistance of Listeria monocytogenes F2365 has been evolved, which cause a major disease listeriosis. The drug dose limit against that pathogen was also increased for currently prescribed anti...
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Lyme disease is an infectious disease caused by a spirochete Borrelia burgdorferi ZS7. This spirochete is most often spread by ticks. Single antibiotic therapy is sufficient for containment of the early stage progression of the disease but combinational therapy is more preferred in later stages. Research is in progress for the development of drugs against the pathogen, but till date no vaccines...
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In silico subtractive/differential genome analysis is a powerful approach for identifying genus or species-specific genes, or groups of genes that are responsible for a unique phenotype. Subtractive genomic approach is one of the most useful strategies helpful in identification of potential drug targets. Availability of genome sequences of pathogens has provided a tremendous amount of informati...
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Objective: In the present study an attempt has been made by the use of a computational approach to investigate putative drug targets in Staphylococcus aureus. Methods: In silico comparative analysis of the metabolic pathways between the pathogen and the Bos taurus was carried out. Further detection of bacterial genes that are non homologous to host, but are essential for the survival of the pat...
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Actinobacillus pleuropneumoniae is a Gram-negative bacterium that resides in the respiratory tract of pigs and causes porcine respiratory disease complex, which leads to significant losses in the pig industry worldwide. The incidence of drug resistance in this bacterium is increasing; thus, identifying new protein/gene targets for drug and vaccine development is critical. In this study, we used...
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ژورنال
عنوان ژورنال: International Journal of Pharmacy and Pharmaceutical Sciences
سال: 2017
ISSN: 0975-1491
DOI: 10.22159/ijpps.2017v9i9.20609